Neurovascular disorders are recognized among the top five life-threatening conditions, accounting for approximately 15 million new cases and five million mortalities annually, across the globe. This increased incidence of neurovascular disorders can be attributed to other underlying pathological conditions, such as diabetes, hypertension and obesity along with poor lifestyle choices. Currently, several conventional approaches, such as microsurgery, bypass surgery and craniotomy are available for treating neurovascular disorders. However, these approaches are incompetent for dealing with various types of neurovascular disorders. This can be attributed to the fact that various types of disorders have unique pathological mechanisms and require a customized and specific approach for treatment. This resulted in the advancements of a targeted technique of therapy involving neurovascular devices, which primarily utilize minimally invasive approach to provide site-specific treatment. Subsequently a lot of neurovascular medical device companies have surfaced in the recent past.
What are Neurovascular Devices?
Neurovascular devices are innovative neuro-interventional devices, which are intended to improve disrupted blood flow to a specific region of the brain. The neurovascular device acts precisely on the damaged blood vessels without disrupting the normal brain vasculature. As a result, neurovascular devices have demonstrated significant increase in the life expectancy of patients suffering with distinct neurovascular disorders and reduction in death rates.
Owing to such positive healthcare outcomes, physicians are proactively engaged in preferring neurovascular devices for the treatment of various neurovascular disorders. This has resulted in increased research and development activities by the neurovascular medical device companies in order to incorporate advanced technologies into different types of neurovascular devices.
The following figure presents the type of neurovascular devices.
Advantages Associated with Neurovascular Devices
The technological advancements introduced by neurovascular medical device companies has created milestones in the treatment of neurovascular disorders. This has proven to be one of the most successful treatment options.
The following figure presents the significant advantages offered by neurovascular devices.
- Site-Specificity: Conventional treatment options are more likely to impose the risk of normal vasculature disruption and delayed recovery rates. In such cases, neurovascular devices provide precise and targeted treatment to a specific site of the brain.
- Reduced Complications: Neurovascular Devices tailors a site-specific treatment based on the type of neurovascular disease treated. The patients receive targeted and minimally invasive treatment, thereby reducing the possible side effects and complications associated with the conventional surgical approaches.
- High Success Rate: Neurovascular devices have demonstrated high success rate in treatment of neurovascular disorders. The neurovascular medical device companies have enhanced the research efforts in improving their neurovascular device portfolio. Notably, over 310 neurovascular devices have been approved and launched in the neurovascular devices market for the treatment of different types of neurovascular disorders
Emerging Innovations from Neurovascular Medical Device Companies
With growing prevalence of neurovascular disorders and increased preference of interventional neurovascular devices, various innovative techniques are proposed to improve both safety and efficacy of these devices. Further, various advancements have been made in the procedures and techniques used to develop and manufacture neurovascular devices. Some of the key trends introduced by neurovascular medical device companies are highlighted below:
Coated Devices
Neurovascular devices can be coated with various medical compounds that are designed to increase efficiency, retention time and decrease corrosion of neurovascular devices. A range of medical device coating have been incorporated in the development of next generation coils and stents, such as drug-based coating, hydrogel-based coating, and stretch-resistant filament-based coating. Moreover, the increase in adoption of this approach has accelerated the deliverability, performance, and duration of neurovascular devices. In November 2023, Surmodics launched an advanced hydrophilic coating, Preside, for neurovascular devices.
Biodegradable Metal-based Devices
Biodegradable metals or their alloys are designed to degrade safely in the body after a decided period of time. Over recent years, the fabrication of biodegradable metals (such as magnesium-alloys) in neurointerventional devices has emerged as a potential method to improve patient care outcomes by overriding the complications associated with conventional materials, such as inflammatory response and thrombosis. In addition, these materials are computed to ensure neuroprotection, cerebral compatibility and hemodynamics following the implantation. Shape Memory’s IMPEDE family of peripheral vascular embolization plugs are biodegradable.
Drug-eluting Devices
Neurovascular devices have revolutionized the treatment of cerebrovascular disorders, however, it renders its own challenges including restenosis and thrombosis. Therefore, innovative strategies such as drug-eluting devices have been introduced to overcome these complications through their ability of slowly releasing drugs and reducing the chances of vessel constriction. In December 2023, Imperative Care initiated a first-in-human clinical trial of its coated neurovascular stent which will help wide-neck intracranial aneurysms patients avoid antiplatelet therapy.
Conjunctive Devices
The conjunctive devices involve the placement of two self-expandable stents parallelly in the cerebral aneurysm, forming a bridge. The approach is focused on increasing the safety and efficacy of coil embolization along with the improved patient care outcomes.
Personalized Devices
Personalized devices provide customization in the treatment approach based on the type of neurovascular disease and patient’s vasculature. Further, these devices are developed using the latest techniques, such as 3D printing. The customization of devices can be achieved by alteration in device angles and diameters to improve the device placement and adaptation to the vascular wall.
Key Innovation Drivers for Neurovascular Medical Device Companies
The adoption of neurovascular devices is increasing due to several driving factors, resulting in the increasing market potential over the coming years.
The following figure presents the key drivers for the neurovascular medical device companies to continue to invest and innovate.
- Increasing Incidence of Neurovascular Disorders: According to the WHO, around 15 million people experience brain stroke each year, globally. This underlines the need for the adoption of innovative neuro interventional techniques and procedures.
- Higher Success Rates: The conventional methods such as endarterectomy and craniotomy have often presented complications. Some of these include disrupting the normal vasculature, lower recovery rate and increased chances of disease recurrence. These pose a significant impact on their clinical utilization. With minimally invasive neurovascular devices, the reliance on such methods and their associated complications can be minimized.
- Catalyst to Enhanced Healthcare: Neurovascular devices, which provide more precise and targeted treatment, have significantly enhanced healthcare outcomes. These positive results have led physicians and government bodies to prioritize the research and development of advanced and innovative devices.
Future Perspectives
The concept of neurovascular devices holds immense potential to transform the treatment approaches for neurovascular disorders. The growing research activities from the neurovascular medical device companies has enabled smooth transition of neurovascular devices from research to clinical application. However, owing to the complex pathophysiology of various neurovascular disorders, researchers are still in the early phases of developing neurovascular disease specific devices and translating it with a technology to reach the most torturous cerebral regions. As a result, there is a need to create advanced technologies that modify the device necessary to make accurate therapeutic inferences and positive patient outcomes.
Although the neurovascular devices market appears to have a promising future, the success will be primarily determined by the efforts made by the neurovascular medical device companies to capitalize on the growth trends and meet demands of the devices.
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