Rilzabrutinib Alleviates Chronic Urticaria Symptoms
TOPLINE: Rilzabrutinib, an oral inhibitor of Bruton tyrosine kinase (BTK), demonstrated a rapid and substantial alleviation of symptoms in patients with chronic spontaneous urticaria (CSU) unresponsive to antihistamines at a dosage of 1200 mg/d compared with placebo. METHODOLOGY: Researchers conducted a 52-week phase 2 trial comprising a 12-week double-blind, placebo-controlled period followed by a 40-week […]
Early Exposure to Antibiotics Increases the Risk of Diabetes Later in Life
Type 1 diabetes is one of the most prevalent chronic conditions in children in the U.S.,1 affecting around four out of every 1,000 youths.2 This autoimmune disease causes the body’s immune system to mistakenly destroy the insulin-producing cells of the pancreas. This leads to lifelong dependence on insulin injections, frequent blood sugar monitoring, and increased […]
Woman Suffocates, Dies During Cryotherapy Session at the Gym Due to Nitrogen Leak
A 29-year-old woman has died and another is in intensive care after a nitrogen leak during a cryotherapy session at a Paris gym led to a fatal case of suffocation, prompting a criminal investigation. Cryotherapy, which exposes the body to extreme cold for therapeutic purposes, typically involves nitrogen gas to achieve ultra-low temperatures. Safety concerns […]
A Pacemaker to Control BP Gets FDA Breakthrough Designation
The US Food and Drug Administration (FDA) has given Breakthrough Device Designation to Orchestra BioMed for its atrioventricular interval modulation (AVIM) therapy for patients with uncontrolled hypertension. AVIM is a pacing algorithm incorporated into dual-chamber pacemakers to treat hypertension. It delivers repeating sequences of shorter and longer atrioventricular delays,lowering blood pressure while simultaneously modulating the […]
What Happens to Your Brain When You Ditch Your Cellphone for Three Days?
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A Handful Of This Nut Daily May Shield You From Colon Cancer
Colon cancer is on the rise, especially in younger adults, and researchers are working hard to figure out risk factors and effective prevention strategies. While genetics play a role, growing evidence suggests that what we choose to eat also plays an important part in both the development and prevention of the disease. A recent study […]
Metabolic Syndrome Ups Mortality Risk in Breast Cancer
TOPLINE: Women diagnosed with metabolic syndrome at the time of their breast cancer diagnosis had a significantly higher risk for recurrence and mortality than those without the condition, according to a meta-analysis of more than 42,000 survivors. METHODOLOGY: Research has shown that women with metabolic syndrome have a higher risk of developing breast cancer and […]
Sugary Drinks Linked to More Than 330,000 Deaths a Year
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‘I Shudder to Think What Could Have Happened to Me’
Beyoncé’s mom, Tina Knowles, has opened up about her private battle with breast cancer and shared and urgent message for other women. The author, who recently published her book “Matriarch,” spoke with People about the harrowing time in her life. In the interview, she reveals that she was diagnosed with stage 1 breast cancer in […]
TILs Plus Pembro Show Efficacy in GI Cancers
Neoantigen-specific tumor-infiltrating lymphocytes (TILs) plus pembrolizumab demonstrate efficacy against treatment-refractory gastrointestinal (GI) cancers in early results from a phase 2 trial. This is the first clinical trial to show that TILs can deliver responses in patients with metastatic GI cancers, making it a notable advance in the efforts to adapt cellular immunotherapy to solid tumors […]